Senior Bioinformatics Scientist Job at Integrated Resources, Inc ( IRI ), Cambridge, MA

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  • Integrated Resources, Inc ( IRI )
  • Cambridge, MA

Job Description

Job Description:

Department: Data and Genome Sciences

Group: Precision Genetics

The Precision Genetics group within the Data and Genome Sciences Department is seeking a skilled Contractor to join our Computational Precision Immunology team. We are looking for a data scientist with extensive experience in multi-modal and multi-scale data analyses to contribute to our innovative research efforts.

Key Responsibilities:

  • Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).
  • RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).
  • Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).
  • Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.
  • Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.

Required Qualifications:

  • Ph.D. in Computational Biology or a related field.
  • A proven track record of over 5 years in multi-omics analysis.
  • Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).
  • Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.
  • Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).
  • A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.
  • Excellent written and verbal communication skills.

Preferred Qualifications:

  • Experience in processing and analyzing real-world data.
  • Familiarity with spatial transcriptomics analysis.
  • Knowledge of statistical and population genetics principles.

Key Skills:

  • Required expertise with multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq.
  • Transcriptomics analysis.
  • Proficiency in R and Bash.
  • High-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).

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